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KMID : 0616120210520030192
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Korean Journal of Pharmacognosy
2021 Volume.52 No. 3 p.192 ~ p.201
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Anti-inflammatory Effect and Analysis of Functional Constituents of Dangguisu-san by Processing Methods
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Jeon Young-Hee
Nam Won-Hee
Leem Hyun-Hee
Kim Se-Jin
Yu Byung-Woo
Son Su-Mi
Kim Myoung-Jin
Choi Hye-Min
Kwon Hyun-Sook
Kim Jung-Ok
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Abstract
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Dangguisu-san (DGSS) is widely known traditional herbal medicinal formula in Korea for treatment of traumatic injury by traffic accident, ecchymosis, abdominal distension and anti-thrombosis of blood. This study was conducted to develop the simultaneous analyze method using high performance liquid chromatography (HPLC) and examine the effect of anti-inflammatory activity of DGSS-dry extract (DGSS-DE) and DGSS-mix extract powder (DGSS-MEP). Physicochemical characteristics of DGSS-DE and DGSS-MEP showed that there is no significant difference in pH, titratable acidity, total soluble solid content and browning degree except for color value (L, a, b). 15 functional constituents of DGSS were identified and the correlation coefficient values of DGSS-DE and DGSS-MEP were conformed 0.950. Also, DGSS-DE and DGSS-MEP significantly decreased the secretion of nitric oxide (NO), prostaglandin E2 (PGE2), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) through inhibited expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), IL-1β, IL-6, and TNF-α. From these result, DGSS-MEP showed similar chemical composition and anti-inflammatory effect to DGSS-DE. Therefore, DGSS-DE and DGSS-MEP may be useful as potential source of drug to prevent inflammation.
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KEYWORD
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Dangguisu-san, Processing method, HPLC, Functional constituent, Anti-inflammatory
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